VÉSALE BIOSCIENCE

Phage therapy

A powerful tool in the fight against antibiotic
multi-resistant
infections

Phage therapy

The therapeutic use of bacteriophages as a treatment for bacterial infections has existed for nearly a century. Today, the decline in the effectiveness of antibiotics renews the interest of scientists in this practice. Conventional phage therapy is based on the use of natural phages to infect and lyse problematic bacteria.

Phages attach to bacterial cells and inject their viral genome into them, producing immediate cell death. The phage then highjacks the bacterial metabolism and forces it to produce additional phage particles which are released at the end of each viral cycle by lysis of the bacterial cell. New infections then begin, and the process multiplies the number of phages exponentially at the expense of the bacteria. This phage-mediated killing rapidly eliminates the majority of the bacterial infection, giving the patient’s own immune system a chance to clean up survivors.

The Phagogram

Phages can be very selective in the strains of bacteria against which they are effective. It is therefore essential to carefully select them so that they match the infection being treated. Current manual methods for this process are time-consuming, labor intensive, and produce results that are challenging to interpret.

Vésale Bioscience has therefore developed an automatic phagogram, an analytical tool capable of choosing and proposing the best correspondence to a certain bacterium among a wide collection of phages. If this operation requires up to a week of work when it is organized in the laboratory by conventional processes, the automatic phagogram performs it in just a few hours. Our Inteliscript program then selects the best corresponding phages for the patient, their clinical isolate, and their indication based on a variety of objective criteria before proposing the optimal phages association to be applied to the patient.

More advantageous than antibiotics

Current research on the use of phages and their lytic proteins, in particular against multidrug-resistant bacterial infections, suggests that phage therapy has the potential to be used as either an alternative or as a complement to antibiotic treatments. Phages are considered more advantageous than antibiotics for different factors:

  • Their specificity
  • Their safety for the host organism but also for other beneficial bacteria such as the intestinal microbiota, thus reducing the risk of opportunistic infections.
  • Their high therapeutic index that presumes few side effects, even beyond the therapeutic level.

Invest to solve the antibiotic resistant crisis

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